2019829ϺƼWWоƸӺԺʿIĿЈFcϺƼWƌWcgWԺƸ99Ʊעƽ̨¼пԺооTn}MڡNature Communicationsϰl}顰Mycobacterial dynamin-like protein IniA mediates membrane fissionоՓȽһYˎTIniAapoBԼGTPYϑBSgYlFƼۯBʽl]ĤѵĹK_IniA ׅcˎܵCQY˲ˎԆ}Ҫָx
Y˲ɽY˷֦UȾlһNԂȾcY˲Ěvʷ150ԏςo~ùҰƽЧˎﱻlFίY˲ԁ@{ĂȾŵԿȻȫĿǰмs1/3˿ڱY˗UȾÿ°l˔ʮصڽ낀oˎʹԼLĂwίѽa˸NˎԽY˲ஔһֲyˎԆ}@Ȟoҵ֮
IniAǷ֦UܱTҪcҰȿYˎˎP99Ʊעƽ̨¼ĽYԼcˎܙCһֱǿհԓоF꠳ɆTX侀wWֶγɹːu֦UIniAapoB3.2ÅֱʣGTPYϠBͺ2.2ÅֱʣSgY״ΰlFIniA ۯBdynaminеļIniAһGTPaseYԼɶYNeckTrunkNeckTrunkʡVŲ@ccynobacteriaBDLPҺxBʽTrunkĩ˴һlipid-interacting (LI) loopw֬|wƯͼɹⶨλLI loopcؓ늺֬ÏĶ嵽ĤоlFcdynaminͬIniAҺвγɺهԵĶwʽLipid tetheringIniAĤγɺهԵľۺϬFMһGiant unilamellar vesicles(GUVs)Supported membrane tubes (SMrTs)иCIniAи׃ĤΑBʹGTPˮهԵĤѹķӻLԁ^Փ99Ʊעƽ̨¼ژܺMϽӽwںأMitofusin, MFN99Ʊעƽ̨¼@һֱJԽ錧Ĥں@헹UĤѶĤںϵ
mȻڌĽ^MչҲһֱ_оˆTIniAͻ׃wˎ܌KʾIniAͨ^錧ĤYϺĤˎڮҰƽY˗UںϳĤȱo׃òדpIniAͨ^ĤѵķʽcĤpޏ99Ʊעƽ̨¼ĶS˼Ĥ˲ԭˎµĴ@ЩlF״ν_IniA 漆QY˲ˎԆ}ṩµľ
ӺԺʿFL҇°lٰlȾԼԭwĽYWо@ԓFڿYIȡõһҪоɹϺƼWӺԺʿIJʿоM_WܽڵIJʿIꖞ鱾ĵĹͬһϺƼWWоӺԺʿF꠹ǸɳɆTоTоT鱾ĵĹͬͨӍͬr99Ʊעƽ̨¼УWоȸоT99Ʊעƽ̨¼оTҲc˴оϺƼWһɆλԓоõ˿ƼȌĿcаlӋ973ӋȻƌWпԺĿĴ֧
Figure 1. aIniAYֲbIniAwY99Ʊעƽ̨¼cSMrTs fission
Փ朽https://www.nature.com/articles/s41467-019-11860-z
Ϻ֖| ^A·393̖֘ 201210 ]: siais@shanghaitech.edu.cn
Copyright © 2018 ϺƼWWо