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Ϻ99Ʊעƽ̨¼ƼWоF꠽ʾIniAcYˎ™C

    2019829ϺƼW߻WоƸӺԺʿIĿЈFcϺƼWƌWcgWԺƸ99Ʊעƽ̨¼пԺооTn}MڡNature Communicationsϰl}顰Mycobacterial dynamin-like protein IniA mediates membrane fissionоՓȽһYˎTIniAapoBԼGTPYϑBSgYlFƼ׵ۯBʽl]ĤѵĹK_IniA ׅcˎܵ™CQY˲ˎԆ}Ҫָx


    Y˲ɽY˷֦UȾlһNԂȾcY˲Ěvʷ150ԏςo~ùҰƽЧˎﱻlFίY˲ԁ@{ĂȾŵԿȻȫĿǰмs1/3˿ڱY˗UȾÿ°l˔ʮصڽ낀oˎʹԼLĂwίѽa˸NˎԽY˲ஔһֲyˎԆ}@Ȟoҵ֮


    IniAǷ֦UܱTҪcҰȿYˎˎP99Ʊעƽ̨¼ĽYԼcˎܙCһֱǿհԓоF꠳ɆTX侀wWֶγɹːu֦UIniA׵apoB3.2ÅֱʣGTPYϠBͺ2.2ÅֱʣSgY״ΰlFIniA ۯBdynaminеļ׼IniAһGTPaseYԼɶYNeckTrunkNeckTrunkʡVŲ@ccynobacteriaBDLP׵ҺxBʽTrunkĩ˴һlipid-interacting (LI) loopw֬|wƯͼɹⶨλLI loopcؓ늺֬໥ÏĶ嵽ĤоlFcdynaminͬIniAҺвγɺهԵĶwʽLipid tetheringIniAĤγɺهԵľۺϬFMһGiant unilamellar vesicles(GUVs)Supported membrane tubes (SMrTs)иCIniAи׃ĤΑBʹGTPˮهԵĤѹ׼ķӻLԁ^Փ99Ʊעƽ̨¼ژܺMϽӽwںأMitofusin, MFN99Ʊעƽ̨¼@һֱJԽ錧Ĥں@헹U׾ĤѶĤںϵ


    mȻڌ׵Ľ^MչҲһֱ_оˆTIniAͻ׃wˎ܌KʾIniAͨ^錧ĤYϺĤˎڮҰƽY˗UںϳĤȱo׃òדpIniAͨ^ĤѵķʽcĤpޏ99Ʊעƽ̨¼ĶS˼Ĥ˲ԭˎµĴ@ЩlF״ν_IniA ׵漆QY˲ˎԆ}ṩµľ


    ӺԺʿFL҇°lٰlȾԼԭwĽYWо@ԓFڿYIȡõһҪоɹϺƼWӺԺʿIJʿоM_WܽڵIJʿIꖞ鱾ĵĹͬһϺƼW߻WоӺԺʿF꠹ǸɳɆTоTоT鱾ĵĹͬͨӍͬr99Ʊעƽ̨¼У߻WоȸоT99Ʊעƽ̨¼оTҲc˴оϺƼWһɆλԓоõ˿ƼȌĿcаlӋ973ӋȻƌWпԺĿĴ֧


Figure 1. aIniAYֲbIniAwY99Ʊעƽ̨¼cSMrTs fission


    Փ朽https://www.nature.com/articles/s41467-019-11860-z



 
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Ϻ֖|…^A·393̖֘ 201210
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